Here, we show functional and transcriptional differences between fibroblast … Here we identify and describe the biology of distinct subsets of fibroblasts responsible for mediating either inflammation or tissue damage in arthritis. Fig. Distinct fibroblast subsets drive inflammation and damage in arthritis. Altmetric Badge. Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms Using Computational Systems Biology Approaches. Objectives Here we identify and describe the biology of a functionally distinct pathogenic fibroblast cell type marked by the co … Distinct fibroblast subsets drive inflammation and damage in arthritis. AbstractObjective. Extended data 8. We show that deletion of FAPα+ fibroblasts suppressed both inflammation and bone erosions in murine models of resolving and persistent arthritis. Nat Rev Rheumatol. 2018;77:175–187. -, Croft AP, et al. The University of Birmingham is ranked amongst the world’s top 100 institutions. This site needs JavaScript to work properly. 2001 Oct;60(5):309-18. doi: 10.1007/s003930170030. Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB. Triaille C, Vansteenkiste L, Constant M, Ambroise J, Méric de Bellefon L, Nzeusseu Toukap A, Sokolova T, Galant C, Coulie P, Carrasco J, Durez P, Lauwerys BR. - Here we identify and describe the biology of distinct subsets of fibroblasts responsible for mediating either inflammation or tissue damage in arthritis. Single-cell transcriptional analysis identified two distinct … 2020 Dec 24;13(1):35. doi: 10.3390/cancers13010035. Clipboard, Search History, and several other advanced features are temporarily unavailable. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2021 Jan 4;10:e62810. Arthritis is an inflammation of one or more joints with symptoms such as joint pain and stiffness (1). Single-cell RNA-sequencing reveals distinct fibroblast subsets. Why remission is not enough: underlying disease mechanisms in RA that prevent cure. 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Extended data 8. Rheumatoid Arthritis (RA) is a common rheumatic disorder characterized by persistent synovial inflammation and destruction of joints. Little is known about fibroblast heterogeneity or if aberrations in fibroblast subsets relate to pathology. Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage. Would you like email updates of new search results? Fingerprint Dive into the research topics of 'Distinct fibroblast subsets drive inflammation and damage in arthritis'. 19791/VAC_/Versus Arthritis/United Kingdom, MR/S025308/1/MRC_/Medical Research Council/United Kingdom, 20015/VAC_/Versus Arthritis/United Kingdom, 21236/VAC_/Versus Arthritis/United Kingdom, R01 AR063759/AR/NIAMS NIH HHS/United States, 14476/VAC_/Versus Arthritis/United Kingdom, G116/131/MRC_/Medical Research Council/United Kingdom, 21743/VAC_/Versus Arthritis/United Kingdom, MR/N026977/1/MRC_/Medical Research Council/United Kingdom, WT104551MA/WT_/Wellcome Trust/United Kingdom, U01 HG009379/HG/NHGRI NIH HHS/United States, UH2 AR067677/AR/NIAMS NIH HHS/United States, R01 HL134375/HL/NHLBI NIH HHS/United States, Baker KF, Isaacs JD. 3. Here we identify and describe the biology of distinct subsets of fibroblasts responsible for mediating either inflammation or tissue damage in arthritis.  |   |  Trajectory analysis and identification…. Single-cell RNA-sequencing reveals distinct fibroblast…. Differential gene expression between fibroblast clusters. Mouse STIA, all cells (Fig. 2016;18:270. We show that deletion of fibroblast activation protein-α (FAPα)+ fibroblasts suppressed both inflammation and bone erosions in mouse models of resolving and persistent arthritis. We show that deletion of FAPα+ synovial cells suppressed both inflammation and bone erosions in murine models of resolving and persistent arthritis. Extended data 5. continued cluster identification analysis. Fibroblasts can have subsets too! Here we identify and describe the biology of distinct subsets of fibroblasts responsible for mediating either inflammation or tissue damage in arthritis. Rheumatoid arthritis is thought to be a distinct subtype of arthritis where the joints undergo progressive inflammation, swelling and pain. 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